Remote loading of doxorubicin into liposomes by transmembrane pH gradient to reduce toxicity toward H9c2 cells
The use of doxorubicin (DOX) is limited by its dose-dependent cardiotoxicity.Entrapped DOX in liposome has been shown to reduce cardiotoxicity.Results showed that about 92% of the total drug was encapsulated in liposome.The release experiments showed a weak DOX leakage in both culture medium and in PBS, more than 98% and 90% of the encapsulated DOX