REMOTE LOADING OF DOXORUBICIN INTO LIPOSOMES BY TRANSMEMBRANE PH GRADIENT TO REDUCE TOXICITY TOWARD H9C2 CELLS

Remote loading of doxorubicin into liposomes by transmembrane pH gradient to reduce toxicity toward H9c2 cells

The use of doxorubicin (DOX) is limited by its dose-dependent cardiotoxicity.Entrapped DOX in liposome has been shown to reduce cardiotoxicity.Results showed that about 92% of the total drug was encapsulated in liposome.The release experiments showed a weak DOX leakage in both culture medium and in PBS, more than 98% and 90% of the encapsulated DOX

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Multiobjective optimization of composite cylindrical shells for strength and frequency using genetic algorithm and neural networks

In this paper, the optimal fiber orientations relative to the principle axis of composite cylindrical shell composed of four and six layers were determined so that the natural frequency and strength of the shell are optimized.For this purpose, first, the free vibration analysis of the shell was carried out based on 3D elasticity.Then, for calculati

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Effectiveness of seven oral traditional Chinese medicines against mild or moderate COVID-19: An updated systematic review and network meta-analysis

Background: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the outbreak of COVID-19 in Wuhan, China.As a highly infectious epidemic, SARS-CoV-2 rapidly evolves.Presently, COVID-19 coexists with humans, mainly with mild or moderate disease.The latest Guidelines for the Diagnosis and Treatment of COVID-19 (trial versi

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Black Carbon Emissions, Transport and Effect on Radiation Forcing Modelling during the Summer 2019–2020 Wildfires in Southeast Australia

The emission of black carbon (BC) particles, which cause atmospheric warming by affecting radiation budget in the atmosphere, is the result of an incomplete combustion process of organic materials.The recent wildfire event during the summer 2019–2020 in south-eastern Australia was unprecedented in scale.The wildfires lasted for nearly 3 months ov

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